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KMID : 0363420060200030117
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Journal of Korean Oriental Pediatrics
2006 Volume.20 No. 3 p.117 ~ p.127
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Inhibitory effect of acute pancreatitis by Gagam-daewhangmokdanpi-tang
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Ahn Jae-Sun
Lee Hai-Ja
Park Eun-Jung
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Abstract
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Objectives: In this study, we investigated the effects of Daehwangmokdanpitang-gagambang(DMG) on treatment for cholecystokinin-octapeptide(CCK)-induced acute pancreatitis(AP) in rats.
Methods: Male Wistar rats weighing 200 to 250 g were divided into three groups. The first was normal untreated group, the second was in treatment with DMG group; DMG was administered orally, followed by 75 CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. The third was in treatment with saline group, the protocol was the same as in treatment group with DMG. We determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP60, HSP72, ERK, p38 MAPK and the secretion of pro-inflammatory cytokines. Repeated CCK treatment resulted in the typical laboratory and morphological changes of experimentally induced pancreatitis.
Results: DMG was significantly decreased the pancreatic weight/body weight ratio in CCKinduced AP and DMG increased HSP60 and HSP72 compared with CCK-induced AP. DMG suppressed ERK and p38 MAPK activation. Additionally, the secretion of and and the levels of amylase and lipase were lower than that saline.
Conclusions: DMG has an effect to treatment for CCK-induced AP.
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KEYWORD
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Daehwangmokdanpitang-gagambang(DMG), pancreatitis, HSPs, ERK, p38IL-1βTNF-α
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